methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate
CAS No.:1418215-07-2
Molecular Formula:C₂₆H₃₇NO₄S
Molecular Weight:459.65
Hs Code.:

Synonyms:methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

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Chemical Property of methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

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Technology Process of methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

There total 11 articles about methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1485470-06-1
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-4-methyl-N-((1s,4S)-4-(4-nitrobenzoyloxy)cyclohexyl)cyclohexanecarboxamido)thiophene-2-carboxylate

: 1418215-07-2
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 4h;
DOI:10.1021/jm401420j

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1418215-07-2
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2.1: pyridine / toluene / 16 h / Reflux

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 - -60 °C

3.2: 3 h / -78 °C

4.1: copper(l) iodide; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

5.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 40 °C

6.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / -25 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

8.1: potassium carbonate; methanol / 4 h / 20 °C

With pyridine; hydrogenchloride; methanol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401420j

Reference yield:

: 55930-23-9
trans-4-methylcyclohexanecarbonyl chloride

: 1418215-07-2
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,4S)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / toluene / 16 h / Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 - -60 °C

2.2: 3 h / -78 °C

3.1: copper(l) iodide; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 40 °C

5.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / -25 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

7.1: potassium carbonate; methanol / 4 h / 20 °C

With pyridine; hydrogenchloride; methanol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401420j