(S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:(S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate
CAS No.:1424168-16-0
Molecular Formula:C₂₁H₂₂N₂O₃S
Molecular Weight:382.483
Hs Code.:

Synonyms:(S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

There total 5 articles about (S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 114604-96-5
tert-butyl 2-formyl-1H-indole-1-carboxylate

: 188447-91-8
(S)-p-toluenesulfinimide

: 1424168-16-0
(S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

Guidance literature:: With titanium(IV) isopropylate; In dichloromethane; for 5h; Reflux;
DOI:10.1002/cjoc.201200672

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1424168-16-0
(S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuryl dichloride / 2 h / 0 °C / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 40 h / 20 °C

4: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

5: titanium(IV) isopropylate / dichloromethane / 5 h / Reflux

With titanium(IV) isopropylate; dmap; manganese(IV) oxide; lithium aluminium tetrahydride; sulfuryl dichloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cjoc.201200672

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 1424168-16-0
(S,Z)-tert-butyl 2-((p-tolylsulfinylimino)methyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

2: manganese(IV) oxide / dichloromethane / 40 h / 20 °C

3: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

4: titanium(IV) isopropylate / dichloromethane / 5 h / Reflux

With titanium(IV) isopropylate; dmap; manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cjoc.201200672