2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester
CAS No.:342411-11-4
Molecular Formula:C₁₅H₂₀N₄O₄
Molecular Weight:320.348
Hs Code.:

Synonyms:2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

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Chemical Property of 2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

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Technology Process of 2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

There total 13 articles about 2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: C₁₅H₁₉NO₇S

: 342411-11-4
2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Guidance literature:: C₁₅H₁₉NO₇S; With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In water; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c4cc06395c

Reference yield: 91.0%

: 158830-39-8
methyl (2S,3S)-2-hydroxy-3-(N-tert-butoxycarbonylamino)-3-phenylpropanoate

: 342411-11-4
2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Guidance literature:: With tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(01)00090-4

Reference yield:

: 7780-06-5
isopropyl cinnamate

: 342411-11-4
2-azido-3-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / K₂OsO₂(OH)4; (DHQ)2-PHAL

2: 93 percent / Et₃N / CH₂Cl₂ / 3 h / 0 - 20 °C

3: 91 percent / NaN₃ / acetone; H₂O / 20 h / 70 °C

4: HCl / 20 h / Heating

5: 325 mg / Et₃N / CH₂Cl₂ / 0 - 20 °C

6: 91 percent / PPh₃; HN₃; diethyl azodicarboxylate / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; sodium azide; potassium dioxotetrahydroxoosmate(VI); (DHQ)2-PHAL; tris-(2-chloro-ethyl)-amine; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; acetone; 1: Sharpless aminohydroxylation / 6: Mitsunobu reaction;
DOI:10.1016/S0040-4020(01)00090-4