3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Base Information

Chemical Name:3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure
CAS No.:122504-67-0
Molecular Formula:C₃₃H₃₃ClN₂O₄
Molecular Weight:557.089
Hs Code.:

Synonyms:3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

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Chemical Property of 3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

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Technology Process of 3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

There total 5 articles about 3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 122504-66-9
N-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-piperazin

: 6515-58-8
3-bromomethylbenzoic acid

: 122504-67-0
3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Guidance literature:: With triethylamine; In toluene; for 4h; Heating;
DOI:10.1002/ardp.19893220606

Reference yield:

: 106-39-8
bromochlorobenzene

: 122504-67-0
3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg / 1.) ether, 2.) reflux, 2 h

2: SOCl₂ / 1.) overnight, 2.) reflux, 1 h

3: toluene / 3 h / Heating

4: 42 percent / Et₃N / toluene / 4 h / Heating

With thionyl chloride; magnesium; triethylamine; In toluene;
DOI:10.1002/ardp.19893220606

Reference yield:

: 2-Benzyloxy-4-[chloro-(4-chloro-phenyl)-methyl]-1-methoxy-benzene

: 122504-67-0
3-4-(4-Chlorphenyl)-(3-benzyloxy-4-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 3 h / Heating

2: 42 percent / Et₃N / toluene / 4 h / Heating

With triethylamine; In toluene;
DOI:10.1002/ardp.19893220606