1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:852049-33-3
Molecular Formula:C₂₉H₃₀N₂O₃
Molecular Weight:454.569
Hs Code.:

Synonyms:1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about 1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 68858-20-8
Fmoc-Val-OH

: 3182-95-4
L-Phenylalaninol

: 852049-33-3
1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With tetrachloromethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol050528e

Reference yield: 97.0%

: 852049-33-3
1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

: 868135-33-5
1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylamine

Guidance literature:: With diethylamine; In methanol; at 20 ℃; for 0.666667h;
DOI:10.1139/V06-188

Reference yield:

: 852049-33-3
1-{(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl}-(1S)-2-methylpropylcarbamic acid 9H-fluoren-9-ylmethyl ester

: (R)-2-[(S)-1-((S)-4-Benzyl-4,5-dihydro-oxazol-2-yl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / methanol / 20 °C

2: 79 percent / DCC / CH₂Cl₂ / 0 - 20 °C

With pyridine; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1021/ol050528e