1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone

Base Information

Chemical Name:1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone
CAS No.:1138338-24-5
Molecular Formula:C₂₇H₃₃ClF₃NO₄
Molecular Weight:528.012
Hs Code.:

Synonyms:1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone

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Chemical Property of 1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone

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Technology Process of 1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone

There total 1 articles about 1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 496807-97-7
3,3-difluoropiperidine hydrochloride

: 1138338-59-6
1-{2-(2-bromo-ethoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone

: 1138338-24-5
1-(3-chloro-6-[2-(3,3-difluoro-piperidin-1-yl)-ethoxy]-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-phenyl)-ethanone

Guidance literature:: 3,3-difluoropiperidine hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2 - 3h;

1-{2-(2-bromo-ethoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 16h;