(S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

Base Information

Chemical Name:(S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate
CAS No.:1342804-40-3
Molecular Formula:C₃₈H₃₈F₃N₃O₆
Molecular Weight:689.731
Hs Code.:

Synonyms:(S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

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Chemical Property of (S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

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Technology Process of (S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

There total 5 articles about (S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1342804-36-7
2-((2S)-4-(1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropylamino)-1-fluorobutan-2-yl)isoindoline-1,3-dione

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: 1342804-40-3
(S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

: 1342804-38-9
(S)-1-(((R)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 1342804-40-3
(S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

: 1342804-38-9
(S)-1-(((R)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: copper(ll) bromide / ethyl acetate; chloroform / 6 h / Reflux

2.1: 15 h / 100 °C / Sealed tube

3.1: lithium borohydride / tetrahydrofuran / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 20 °C

5.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

6.1: pentane; tetrahydrofuran / 3 h / -78 °C

6.2: -78 °C

6.3: -78 °C

7.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 0 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; lithium borohydride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; ethyl acetate; pentane;

Reference yield:

: 292858-05-0
ethyl 3-bromo-2-oxo-4-phenylbutanoate

: 1342804-40-3
(S)-1-(((S)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

: 1342804-38-9
(S)-1-(((R)-1-(5-benzyl-2-(2,5-difluorophenyl)oxazol-4-yl)-2,2-dimethylpropyl)((S)-3-(1,3-dioxoisoindolin-2-yl)-4-fluorobutyl)amino)-1-oxopropan-2-yl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 15 h / 100 °C / Sealed tube

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

5.1: pentane; tetrahydrofuran / 3 h / -78 °C

5.2: -78 °C

5.3: -78 °C

6.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 20 °C

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 0 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; lithium borohydride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; pentane;