1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde

Base Information

• Chemical Name: 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde
• CAS No.: 317829-98-4
• Molecular Formula: C₁₈H₂₄N₂O₅
• Molecular Weight: 348.399
• Mol file: 317829-98-4.mol

Synonyms:1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde

Chemical Property of 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde

There total 11 articles about 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(benzyloxycarbonyl)-2-hydroxymethyl-4-(tert-butyloxycarbonyl)-piperazine (317365-33-6,529516-61-8) → 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde (317829-98-4)

Guidance literature:

1-(benzyloxycarbonyl)-2-hydroxymethyl-4-(tert-butyloxycarbonyl)-piperazine; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 ℃; for 0.333333h;

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 89.0%

O1-benzyl O4-tert-butyl (2S)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate (529516-61-8) → 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde (317829-98-4)

Guidance literature:

O₁-benzyl O₄-tert-butyl (2S)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -78 ℃; for 1.5h; Inert atmosphere;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 0.5h;

Reference yield:

O1-benzyl-O4-tert-butyl 2-(N-methoxy-N-methylcarbamoyl)piperazine-1,4-dicarboxylate → 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde (317829-98-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -40 ℃; for 1h;

upstream raw materials:

1-(benzyloxycarbonyl)-2-hydroxymethyl-4-(tert-butyloxycarbonyl)-piperazine

tert-butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate

di-tert-butyl dicarbonate

2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester

Downstream raw materials:

1-benzyl 4-tert-butyl 2-vinylpiperazine-1,4-dicarboxylate