2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

Base Information

Chemical Name:2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate
CAS No.:1190423-39-2
Molecular Formula:C₃₄H₃₆N₆O₄
Molecular Weight:592.698
Hs Code.:

Synonyms:2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

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Chemical Property of 2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

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Technology Process of 2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

There total 7 articles about 2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190423-38-1
C₃₃H₃₀FN₅O₄

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 1190423-39-2
2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

Guidance literature:: C₃₃H₃₀FN₅O₄; trans-4-hydroxycyclohexylamine; With potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 1.25h; microwave irradiation;

With water; dihydrogen peroxide; sodium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1190423-39-2
2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 15 h / 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / Inert atmosphere; Reflux

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

4.1: potassium carbonate / dimethyl sulfoxide / 1.25 h / 90 °C / microwave irradiation

4.2: 1 h / 20 °C

With dmap; potassium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1190423-39-2
2-methylpropan-2-yl [5-(9-{4-carbamoyl-3-[(4-trans-hydroxycyclohexyl)amino]phenyl}-9H-carbazol-4-yl)pyrimidin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

2.1: potassium carbonate / dimethyl sulfoxide / 1.25 h / 90 °C / microwave irradiation

2.2: 1 h / 20 °C

With potassium carbonate; caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dimethyl sulfoxide;