2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Base Information

Chemical Name:2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide
CAS No.:1244642-01-0
Molecular Formula:C₃₁H₂₈F₃N₇O₃S₂
Molecular Weight:667.736
Hs Code.:

Synonyms:2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Suppliers and Price of 2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

There total 10 articles about 2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 52023-68-4
6-(morpholin-4-yl)pyridin-3-amine

: 1195768-43-4
N-{5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

: 1244642-01-0
2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: 6-(morpholin-4-yl)pyridin-3-amine; N-{5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; In methanol; butan-1-ol; at 170 ℃; for 1h; Inert atmosphere; microwave irradiation;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1351161-81-3
C₁₄H₁₀F₃NO₄S

: 1244642-01-0
2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane

2: N-Bromosuccinimide / N,N-dimethyl-formamide

4: hydrogenchloride; 2,2,2-trifluoroethanol / water / 180 °C / Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; 2,2,2-trifluoroethanol; lithium hexamethyldisilazane; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.021

Reference yield:

: 1195768-42-3
N-{5-[(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

: 1244642-01-0
2,6-difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide

3: hydrogenchloride; 2,2,2-trifluoroethanol / water / 180 °C / Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; 2,2,2-trifluoroethanol; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.021