2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Chemical Name:2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide
CAS No.:1313043-74-1
Molecular Formula:C₃₂H₃₀F₅N₃O₃
Molecular Weight:599.601
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

There total 1 articles about 2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1313043-12-7
N-(3-{1-[4-bromo-1-(2-methoxy-ethyl)-1H-indole-3-carbonyl]-piperidin-4-yl}-4-fluoro-benzyl)-2,2,2-trifluoro-acetamide

: 1765-93-1
4-fluoroboronic acid

: 1313043-74-1
2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃;

Reference yield: 76.0%

: 1313043-74-1
2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

: 1313040-87-7
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indol-3-yl]-methanone hydrochloride

Guidance literature:: 2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-(4-fluoro-phenyl)-1-(2-methoxy-ethyl)-1H-indole3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide; With water; potassium carbonate; In methanol; at 45 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane;