Technology Process of 4',4'''-dihydroxy-6,6''-biflavone
There total 7 articles about 4',4'''-dihydroxy-6,6''-biflavone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4',4'''-dimethoxy-6,6''-biflavone;
With
boron tribromide;
In
dichloromethane;
at -60 - 20 ℃;
for 168h;
Inert atmosphere;
With
water;
In
dichloromethane;
Cooling with ice;
DOI:10.1016/j.bmc.2011.04.010
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper / 2 h / 200 - 220 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere
2.2: 24.25 h / 20 °C
3.1: iodine / dimethyl sulfoxide / 1 h / 190 °C / Reflux
4.1: boron tribromide / dichloromethane / 168 h / -60 - 20 °C / Inert atmosphere
4.2: Cooling with ice
With
iodine; boron tribromide; copper; sodium hydride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; mineral oil;
1.1: Ullmann reaction / 2.2: Aldol condensation;
DOI:10.1016/j.bmc.2011.04.010
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux
2.1: iodine; iodic acid; acetic acid / ethanol; water / 1 h / Reflux
3.1: copper / 2 h / 200 - 220 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere
4.2: 24.25 h / 20 °C
5.1: iodine / dimethyl sulfoxide / 1 h / 190 °C / Reflux
6.1: boron tribromide / dichloromethane / 168 h / -60 - 20 °C / Inert atmosphere
6.2: Cooling with ice
With
iodine; boron tribromide; iodic acid; copper; sodium hydride; potassium carbonate; acetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
3.1: Ullmann reaction / 4.2: Aldol condensation;
DOI:10.1016/j.bmc.2011.04.010
