Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

Base Information

Chemical Name:Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate
CAS No.:137840-00-7
Molecular Formula:C₂₆H₃₁N₅O₇S₂
Molecular Weight:589.693
Hs Code.:

Synonyms:Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

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Chemical Property of Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

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Technology Process of Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

There total 8 articles about Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 137839-99-7
Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-succinimidopenicillanate

: 137840-00-7
Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

Guidance literature:: With hydrogen sulfide; triethylamine; In dichloromethane; at 0 - 5 ℃; for 1h;

Reference yield:

: 63422-71-9
(R)-α-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]benzeneacetic acid

: 137840-00-7
Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 1 h / Ambient temperature

2: 45 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 44 percent / AgOAc / dimethylformamide / 1 h / Ambient temperature

4: 51 percent / H₂S, NEt₃ / CH₂Cl₂ / 1 h / 0 - 5 °C

With pyridine; oxalyl dichloride; hydrogen sulfide; triethylamine; N,N-dimethyl-formamide; silver(I) acetate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 87106-48-7
Toluene-p-sulphonate of Allyl 6β-Aminopenicillanate

: 137840-00-7
Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate

Guidance literature:: Multi-step reaction with 6 steps

2: K₂CO₃ / dimethylformamide / 0 deg C, 1.5 h, rt, 1h

3: 2,4-dinitrophenylhydrazine, p-TsOH / ethanol; CHCl₃ / 1 h / Ambient temperature

4: 45 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

5: 44 percent / AgOAc / dimethylformamide / 1 h / Ambient temperature

6: 51 percent / H₂S, NEt₃ / CH₂Cl₂ / 1 h / 0 - 5 °C

With pyridine; hydrogen sulfide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; (2,4-dinitro-phenyl)-hydrazine; silver(I) acetate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;