methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate
CAS No.:1445787-38-1
Molecular Formula:C₂₇H₂₅N₅O₅
Molecular Weight:499.526
Hs Code.:

Synonyms:methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Suppliers and Price of methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

There total 5 articles about methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.9%

: 1445790-64-6
methyl 1-(3-nitrophenyl)cyclopropane-1-carboxylate

: 1374867-83-0
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

: 1445787-38-1
methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Guidance literature:: methyl 1-(3-nitrophenyl)cyclopropane-1-carboxylate; With palladium 10% on activated carbon; hydrogen; acetic acid; at 20 ℃; for 1h; under 2068.65 Torr;

4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide;

Reference yield:

: 10268-12-9
methyl 3-nitrophenylacetate

: 1445787-38-1
methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil

2: hydrogen; acetic acid; palladium 10% on activated carbon / 1 h / 20 °C / 2068.65 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1877-73-2
3-nitro-benzeneacetic acid

: 1445787-38-1
methyl 1-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: chloro-trimethyl-silane / 2 h

2: sodium hydride / N,N-dimethyl-formamide; mineral oil

3: hydrogen; acetic acid; palladium 10% on activated carbon / 1 h / 20 °C / 2068.65 Torr

With chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; In N,N-dimethyl-formamide; mineral oil;