(R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Base Information

Chemical Name:(R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin
CAS No.:946002-05-7
Molecular Formula:C₁₈H₁₈O₆
Molecular Weight:330.337
Hs Code.:

Synonyms:(R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Suppliers and Price of (R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

There total 4 articles about (R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946001-97-4
(1R)-2-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanol

: 946002-05-7
(R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

: (S)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Guidance literature:: (1R)-2-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanol; With silica gel; In dichloromethane; at 30 ℃; for 96h;

With lithium chloride; In N,N-dimethyl-formamide; at 150 ℃; for 17h; Further stages. Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2007.04.092

Reference yield:

: 946001-52-1
(S)-4-isopropyl-2-(2-methoxy-6-methylphenyl)-4,5-dihydrooxazole

: 946002-05-7
(R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C

1.2: diethyl ether; hexane; cyclohexane / -78 - 20 °C

2.1: silica gel / CH₂Cl₂ / 96 h / 30 °C

2.2: LiCl / dimethylformamide / 17 h / 150 °C

With sec.-butyllithium; silica gel; In diethyl ether; hexane; dichloromethane; cyclohexane;
DOI:10.1016/j.tet.2007.04.092

Reference yield:

: 50463-84-8
2-methoxy-6-methylbenzoyl chloride

: 946002-05-7
(R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / CH₂Cl₂ / 0 - 20 °C

1.2: 3.80 g / methanesulfonyl chloride / CH₂Cl₂ / 0 - 20 °C

2.1: sec-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C

2.2: diethyl ether; hexane; cyclohexane / -78 - 20 °C

3.1: silica gel / CH₂Cl₂ / 96 h / 30 °C

3.2: LiCl / dimethylformamide / 17 h / 150 °C

With sec.-butyllithium; silica gel; triethylamine; In diethyl ether; hexane; dichloromethane; cyclohexane;
DOI:10.1016/j.tet.2007.04.092