4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol

Base Information

• Chemical Name: 4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol
• CAS No.: 57366-19-5
• Molecular Formula: C₂₄H₂₅N₅O₃
• Molecular Weight: 431.494
• Mol file: 57366-19-5.mol

Synonyms:4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol

Chemical Property of 4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol

There total 1 articles about 4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Chloro-1-phenyltetrazole (14210-25-4) + dihydromorphine (509-60-4,13004-73-4,26626-12-0) → 4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol (57366-19-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jm00189a007

Reference yield:

4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol (57366-19-5) → 4,5α-epoxy-6-oxo-7β-phenylselanyl-morphinane-17-carboxylic acid ethyl ester (69663-76-9)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd-C / acetic acid

2: KOtBu, Ph₂CO / benzene / 0.83 h / 85 - 90 °C

3: benzene / Heating

4: HCl / ethyl acetate / 25 °C

With hydrogenchloride; benzophenone; potassium tert-butylate; hydrogen; palladium on activated charcoal; In acetic acid; ethyl acetate; benzene;

DOI:10.1021/jm00189a007

Reference yield:

4,5α-epoxy-17-methyl-3-(1-phenyl-1H-tetrazol-5-yloxy)-morphinan-6α-ol (57366-19-5) → 4,5α-epoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane (60942-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / acetic acid

2: Py / 72 h / 25 °C

With pyridine; hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00189a007

upstream raw materials:

5-Chloro-1-phenyltetrazole

dihydromorphine

Downstream raw materials:

4,5α-epoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane

4,5α-epoxy-6-oxo-7β-phenylselanyl-morphinane-17-carboxylic acid ethyl ester