N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

Base Information

Chemical Name:N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester
CAS No.:70990-90-8
Molecular Formula:C₂₁H₂₄N₂O₈S
Molecular Weight:464.496
Hs Code.:

Synonyms:N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

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Chemical Property of N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

Chemical Property:

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Technology Process of N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

There total 11 articles about N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 55027-83-3
2-(toluene-4-sulphonyl)ethyl chloroformate

: 5-(2-Amino-2-methoxycarbonyl-ethyl)-pyridine-2-carboxylic acid methyl ester; hydrochloride

: 70990-90-8
N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

Guidance literature:: With triethylamine; In chloroform; for 12h; Ambient temperature;

Reference yield:

: 4434-13-3
2-carboxy-5-methylpyridine

: 70990-90-8
N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / conc. H₂SO₄ / 14 h / Heating

2: 67 percent / N-bromosuccinimide, dibenzoylperoxide / CCl₄ / 3 h / 60 - 80 °C / Irradiation

3: 72 percent / Na / ethanol; benzene / 1) reflux, 7 h, 2) room temperature, 10 h

4: 96 percent / 48percent HBr / 6 h / Heating

5: HCl / 2 h / Heating

6: 37 percent / Et₃N / CHCl₃ / 12 h / Ambient temperature

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; hydrogen bromide; sodium; triethylamine; dibenzoyl peroxide; In tetrachloromethane; ethanol; chloroform; benzene;

Reference yield:

: 55876-82-9
5-methyl-2-pyridinecarboxylic acid-ethyl ester

: 70990-90-8
N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / N-bromosuccinimide, dibenzoylperoxide / CCl₄ / 3 h / 60 - 80 °C / Irradiation

2: 72 percent / Na / ethanol; benzene / 1) reflux, 7 h, 2) room temperature, 10 h

3: 96 percent / 48percent HBr / 6 h / Heating

4: HCl / 2 h / Heating

5: 37 percent / Et₃N / CHCl₃ / 12 h / Ambient temperature

With hydrogenchloride; N-Bromosuccinimide; hydrogen bromide; sodium; triethylamine; dibenzoyl peroxide; In tetrachloromethane; ethanol; chloroform; benzene;