4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile

Base Information

• Chemical Name: 4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile
• CAS No.: 1052100-30-7
• Molecular Formula: C₂₀H₂₆N₄O₂
• Molecular Weight: 354.452

Synonyms:4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile

Chemical Property of 4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile

Chemical Property:

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Technology Process of 4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile

There total 1 articles about 4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-[3-(tetrahydropyran-2-yloxy)-propylamino]-benzonitrile (1052100-29-4) + 5-chloromethyl-1-methyl-1H-imidazole hydrochloride (90773-41-4) → 4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile (1052100-30-7)

Guidance literature:

4-[3-(tetrahydropyran-2-yloxy)-propylamino]-benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

5-chloromethyl-1-methyl-1H-imidazole hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm800113p

Reference yield: 88.0%

4-[(3-methyl-3H-imidazol-4-ylmethyl)-{3-(tetrahydropyran-2-yloxy)-propyl}-amino]-benzonitrile (1052100-30-7) → 4-[(3-hydroxypropyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-benzonitrile (1052100-31-8)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm800113p

upstream raw materials:

4-[3-(tetrahydropyran-2-yloxy)-propylamino]-benzonitrile

5-chloromethyl-1-methyl-1H-imidazole hydrochloride

Downstream raw materials:

4-[(3-hydroxypropyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-benzonitrile

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