(S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester
• CAS No.: 158197-30-9
• Molecular Formula: C₁₈H₂₃NO₅
• Molecular Weight: 333.384
• Mol file: 158197-30-9.mol

Synonyms:(S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester

Chemical Property of (S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-3-oxopropyl)zinc(II) iodide + acryloyl chloride (814-68-6,25189-84-8) → (S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester (158197-30-9)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl acetamide; benzene; ultrasonication;

DOI:10.1016/S0040-4039(00)73372-7

Reference yield: 100.0%

(S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester (158197-30-9) → 4-oxopipecolic acid benzyl ester

Guidance literature:

With hydrogenchloride; In diethyl ether; for 48h;

DOI:10.1016/S0040-4039(00)73372-7

Reference yield: 72.0%

(S)-2-tert-Butoxycarbonylamino-4-oxo-hex-5-enoic acid benzyl ester (158197-30-9) + benzylamine (100-46-9) → (S)-6-Benzylamino-2-tert-butoxycarbonylamino-4-oxo-hexanoic acid benzyl ester

Guidance literature:

In diethyl ether; for 72h; Ambient temperature;

DOI:10.1016/S0040-4039(00)73372-7

upstream raw materials:

acryloyl chloride