3-Methoxymethylphenylboronic acid

Base Information

• Chemical Name: 3-Methoxymethylphenylboronic acid
• CAS No.: 142273-84-5
• Molecular Formula: C8H11BO3
• Molecular Weight: 165.985
• Hs Code.: 2931900090
• European Community (EC) Number: 800-834-2
• DSSTox Substance ID: DTXSID10396941
• Wikidata: Q72490589
• Mol file: 142273-84-5.mol

Synonyms:142273-84-5;3-Methoxymethylphenylboronic acid;(3-(Methoxymethyl)phenyl)boronic acid;3-(METHOXYMETHYL)PHENYLBORONIC ACID;[3-(methoxymethyl)phenyl]boronic Acid;3-(Methoxymethyl)benzeneboronic acid;3-METHOXYMETHYLPHEBYLBORONIC ACID;3-Methoxymethylbenzeneboronic acid;Peonidinchloride;SCHEMBL8528;DTXSID10396941;XOSGESMDNPVZKS-UHFFFAOYSA-N;3-Methoxymethyl benzeneboronic acid;(3-(Methoxymethyl)phenyl)boronicacid;MFCD03412069;AKOS004116557;AM86590;PS-9447;{3-[(methyloxy)methyl]phenyl}boronic acid;Boronic acid, B-[3-(methoxymethyl)phenyl]-;CS-0176150;FT-0605414;3-methoxymethylphenylboronic acid, AldrichCPR;I12235;EN300-1259728;A807881

Chemical Property of 3-Methoxymethylphenylboronic acid

Chemical Property:

• Vapor Pressure: 0.00026mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 310.3 °C at 760 mmHg
• PKA: 8.32±0.10(Predicted)
• Flash Point: 141.5 °C
• PSA: 49.69000
• Density: 1.13 g/cm³
• LogP: -0.48720
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.0801244
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

97% ^*data from raw suppliers

(3-(Methoxymethyl)phenyl)boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=CC(=CC=C1)COC)(O)O

Technology Process of 3-Methoxymethylphenylboronic acid

There total 1 articles about 3-Methoxymethylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(methoxymethyl)bromobenzene (1515-89-5) → 3-(methoxymethyl)phenylboronic acid (142273-84-5)

Guidance literature:

Reference yield: 84.0%

8-bromo-1,6-naphthyridine-2-carboxamide (875514-62-8) + 3-(methoxymethyl)phenylboronic acid (142273-84-5) → 8-(3-(methoxymethyl)phenyl)-1,6-naphthyridine-2-carboxamide (1611472-79-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 2h;

Reference yield: 82.0%

5-bromo-2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine (1278250-11-5) + 3-(methoxymethyl)phenylboronic acid (142273-84-5) → 2-(4-chlorophenyl)-5-(3-methoxymethylphenyl)pyrazolo[1,5-a]pyridine (1278652-47-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; water; at 70 ℃; for 2h;

upstream raw materials:

3-(methoxymethyl)bromobenzene

Downstream raw materials:

(E)-N-t-butoxycarbonyl-2-fluoro-4-(3-methoxymethylphenyl)-2-butenylamine

(1-cyclohexyl-2-(5-(3-(methoxymethyl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol

9-(4,6-dimethylpyrimidin-2-yl)-2-((5-(3-(methoxymethyl)phenyl)-2-methyl-2H-1,2,3-triazol-4-yl)methyl)-2,9-diazaspiro[5.5]undecan-1-one

C₁₈H₂₃N₃O₄S