(S)-α-deuteriobenzyl chloride

Base Information

Chemical Name:(S)-α-deuteriobenzyl chloride
CAS No.:51348-69-7
Molecular Formula:C₇H₇Cl
Molecular Weight:127.578
Hs Code.:

Synonyms:(S)-α-deuteriobenzyl chloride

Suppliers and Price of (S)-α-deuteriobenzyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-α-deuteriobenzyl chloride

Chemical Property:

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Technology Process of (S)-α-deuteriobenzyl chloride

There total 9 articles about (S)-α-deuteriobenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3481-15-0,4181-90-2,52949-66-3,4546-45-6
benzyl alcohol-d1

: 4181-91-3
(R)-(-)-benzyl-α-d chloride

: 51348-69-7
(S)-α-deuteriobenzyl chloride

Guidance literature:: With trichlorophosphate; In pyridine; dichloromethane; Title compound not separated from byproducts;
DOI:10.1021/ja00341a083

Reference yield:

: 3592-47-0
Benzaldehyde-d

: 51348-69-7
(S)-α-deuteriobenzyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / R-Alpine-Borane / tetrahydrofuran / 1.5 h / Heating

2: Mitsunobu chlorination reagents

With B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; Mitsunobu chlorination reagents; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1016/S0957-4166(02)00487-1

Reference yield:

: 4181-90-2
(R)-(α-2H)benzyl alcohol

: 51348-69-7
(S)-α-deuteriobenzyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃ / 48 h / 25 °C

2: hypochlorite / dimethylsulfoxide; H₂O; pentane / 15 °C

3: MeCN / 24 h / 25 °C

With sodium hypochlorite; acetonitrile; In chloroform; water; dimethyl sulfoxide; pentane;
DOI:10.1016/S0040-4039(00)97714-1