Technology Process of [(3-bromo-2-methylphenyl)methyl]amine hydrochloride
There total 7 articles about [(3-bromo-2-methylphenyl)methyl]amine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromo-2-methylbenzamide;
With
dimethylsulfide borane complex;
Reflux;
With
methanol;
at 20 ℃;
for 0.166667h;
With
hydrogenchloride;
In
water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / N,N-dimethyl-formamide / 20 °C
2.1: dimethylsulfide borane complex / Reflux
2.2: 0.17 h / 20 °C
2.3: 1 h / 20 °C
With
dimethylsulfide borane complex; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine; iron / chloroform / 48 h / 40 °C / Reflux
2.1: tin(II) chloride dihdyrate / tetrahydrofuran; ethanol / 3 h / 20 °C
2.2: 1.5 h
3.1: hydrogenchloride / water / 0.33 h
3.2: 2 h / 0 - 5 °C
3.3: 0 - 20 °C
4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -80 - -76 °C
4.2: -80 °C
4.3: pH 1
5.1: thionyl chloride / toluene / 2 h / Reflux
6.1: ammonia / tetrahydrofuran; toluene / 1 h
7.1: dimethylsulfide borane complex / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
7.2: 0.17 h
7.3: 1 h
With
hydrogenchloride; thionyl chloride; tin(II) chloride dihdyrate; dimethylsulfide borane complex; ammonia; bromine; tert.-butyl lithium; iron;
In
tetrahydrofuran; ethanol; chloroform; water; toluene; pentane;
