alpha,alpha-Bis(4-chlorophenyl)-4-piperidinemethanol

Base Information

Chemical Name:alpha,alpha-Bis(4-chlorophenyl)-4-piperidinemethanol
CAS No.:67853-64-9
Molecular Formula:C₁₈H₁₉Cl₂NO
Molecular Weight:336.261
Hs Code.:
DSSTox Substance ID:DTXSID701259039

Synonyms:alpha,alpha-bis(4-chlorophenyl)-4-piperidinemethanol;SCHEMBL9786895;BWXZFPRLNQFEFD-UHFFFAOYSA-N;DTXSID701259039;67853-64-9

Suppliers and Price of alpha,alpha-Bis(4-chlorophenyl)-4-piperidinemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha,alpha-Bis(4-chlorophenyl)-4-piperidinemethanol

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:335.0843696
Heavy Atom Count:22
Complexity:321

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1C(C2=CC=C(C=C2)Cl)(C3=CC=C(C=C3)Cl)O

Technology Process of alpha,alpha-Bis(4-chlorophenyl)-4-piperidinemethanol

There total 6 articles about alpha,alpha-Bis(4-chlorophenyl)-4-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 117022-60-3
4--N,N-diethyl-1-piperidinecarboxamide

: 67853-64-9
α,α-Bis(4-chlorophenyl)-4-piperidinemethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Heating;
DOI:10.1021/jm00121a022

Reference yield:

: 106-39-8
bromochlorobenzene

: 67853-64-9
α,α-Bis(4-chlorophenyl)-4-piperidinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 35 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

With lithium aluminium tetrahydride; magnesium; In tetrahydrofuran;
DOI:10.1021/jm00121a022

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 67853-64-9
α,α-Bis(4-chlorophenyl)-4-piperidinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

3: 35 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

With lithium aluminium tetrahydride; magnesium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00121a022