3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

Base Information

Chemical Name:3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole
CAS No.:865787-07-1
Molecular Formula:C₂₀H₂₂N₄O₂S
Molecular Weight:382.486
Hs Code.:

3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[<i>d</i>]isothiazole

Synonyms:3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

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Chemical Property of 3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

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Technology Process of 3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

There total 2 articles about 3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-47-9
4-tolylacetic acid

: 865787-07-1
3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / TFAA; NH₄NO₃ / CHCl₃

2: 50 percent / BOP-Cl; Et₃N / CH₂Cl₂

3: 49 percent / BH₃*SMe₂ / toluene / Heating

With ammonium nitrate; dimethylsulfide borane complex; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic anhydride; In dichloromethane; chloroform; toluene;
DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

: 29640-90-2
(4-methyl-2-nitro-phenyl)-acetic acid

: 865787-07-1
3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / BOP-Cl; Et₃N / CH₂Cl₂

2: 49 percent / BH₃*SMe₂ / toluene / Heating

With dimethylsulfide borane complex; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.06.097