1-Oxo-25-hydroxyprevitamin D₃

Base Information

• Chemical Name: 1-Oxo-25-hydroxyprevitamin D₃
• CAS No.: 66760-28-9
• Molecular Formula: C₂₇H₄₂O₃
• Molecular Weight: 414.629
• Mol file: 66760-28-9.mol

Synonyms:1-Oxo-25-hydroxyprevitamin D₃

Chemical Property of 1-Oxo-25-hydroxyprevitamin D₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Oxo-25-hydroxyprevitamin D₃

There total 1 articles about 1-Oxo-25-hydroxyprevitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

calcitriol (32222-06-3) → 1-Oxo-25-hydroxyprevitamin D3 (66760-28-9)

Guidance literature:

With Dess-Martin periodane; In acetonitrile; for 2h; Ambient temperature;

DOI:10.1021/jo00059a048

Reference yield: 69.0%

1-Oxo-25-hydroxyprevitamin D3 (66760-28-9) → (1R,3R)-5-{(Z)-2-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1021/jo00059a048

Reference yield: 25.0%

methyllithium (917-54-4) + 1-Oxo-25-hydroxyprevitamin D3 (66760-28-9) → Previtamin D (163011-08-3) + (1R,3R)-5-{(Z)-2-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-3,4-dimethyl-cyclohex-4-ene-1,3-diol

Guidance literature:

In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.166667h;

DOI:10.1021/jo00111a047

upstream raw materials:

calcitriol

Downstream raw materials:

calcitriol

[2H]-Pre-1,25-D₃

Previtamin D