methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

Base Information

Chemical Name:methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate
CAS No.:1334541-33-1
Molecular Formula:C₂₇H₃₇N₃O₆
Molecular Weight:499.607
Hs Code.:

Synonyms:methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

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Chemical Property of methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

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Technology Process of methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

There total 7 articles about methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 44565-27-7,44565-28-8,64070-19-5,88390-32-3
4-amino-2-methyl-1-butanol

: 1334541-33-1
methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / 0 - 20 °C

2.2: 20 °C

3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.33 h / -78 °C

3.2: 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / -30 °C

4.2: -10 °C

4.3: 3 h / -78 - 10 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dichloromethane; 1,4-dioxane / 3 h / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

Reference yield:

: 1334541-28-4
1-phenyl-4-(tributylstannyl)-1H-imidazole

: 1334541-32-0
methyl (2E)-6-[bis(tert-butoxycarbonyl)amino]-2-bromo-4-methylhex-2-enoate

: 1334541-33-1
methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; for 3h; Reflux;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1334541-33-1
methyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-(1-phenyl-1H-imidazol-4-yl)hex-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / 0 - 20 °C

2.2: 20 °C

3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.33 h / -78 °C

3.2: 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / -30 °C

4.2: -10 °C

4.3: 3 h / -78 - 10 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dichloromethane; 1,4-dioxane / 3 h / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;