N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426666-57-0
Molecular Formula:C₂₁H₂₂N₆O₃
Molecular Weight:406.444
Hs Code.:

Synonyms:N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 6 articles about N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4835-90-9
3-Hydroxy-2,2-dimethylpropanoic acid

: 1426136-11-9
(E)-N-(5-(2-hydroxyguanidino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426666-57-0
N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 3-Hydroxy-2,2-dimethylpropanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(E)-N-(5-(2-hydroxyguanidino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

Reference yield:

: 660838-05-1
t-butyl 3-amino-4-methylphenylcarbamate

: 1426666-57-0
N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

1.2: 20 °C

2.1: dimethylsulfide; trifluoroacetic acid / dichloromethane / 2 h

3.1: potassium acetate / methanol / 0.08 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: hydroxylamine / ethanol; water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 4 h / 100 °C

With oxalyl dichloride; dimethylsulfide; hydroxylamine; potassium acetate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1426136-50-6
tert-butyl 3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenylcarbamate

: 1426666-57-0
N-(5-((5-(1-hydroxy-2-methylpropan-2-yl)-1,2,4-oxadiazol-3-yl)amino)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide; trifluoroacetic acid / dichloromethane / 2 h

2.1: potassium acetate / methanol / 0.08 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydroxylamine / ethanol; water / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 4 h / 100 °C

With dimethylsulfide; hydroxylamine; potassium acetate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;