N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroacetamide
• CAS No.: 220294-74-6
• Molecular Formula: C₁₀H₅F₃N₂O₃
• Molecular Weight: 258.157
• Mol file: 220294-74-6.mol

Synonyms:N-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2,2,2-trifluoro-acetamide

Chemical Property of N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroacetamide

There total 4 articles about N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-aminophthalamide (1875-48-5) + trifluoroacetic anhydride (407-25-0) → N-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2,2,2-trifluoro-acetamide (220294-74-6)

Guidance literature:

at 0 ℃; for 2h;

DOI:10.1039/a807230b

Reference yield:

phthalic anhydride (85-44-9) → N-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2,2,2-trifluoro-acetamide (220294-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.08 h / 20 °C

2: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1 h

3: acetic acid; triethylamine / tetrahydrofuran / 1 h / Heating

With acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1: Acylation / 2: Cyclization / 3: Isomerization;

DOI:10.1021/jo000225s

Reference yield:

trifluoro-acetic acid (3-oxo-3H-isobenzofuran-1-ylidene)-hydrazide → N-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2,2,2-trifluoro-acetamide (220294-74-6)

Guidance literature:

With acetic acid; triethylamine; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/jo000225s

upstream raw materials:

N-aminophthalamide

trifluoroacetic anhydride

phthalic anhydride

2-[N'-(2,2,2-Trifluoro-acetyl)-hydrazinocarbonyl]-benzoic acid

Downstream raw materials:

2,2,2-trifluoroacetohydrazide

N-benzyl-N-trifluoromethylcarbonylaminophthalimide

2-benzylamino-1H-isoindole-1,3(2H)-dione

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