{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Base Information

Chemical Name:{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester
CAS No.:918299-71-5
Molecular Formula:C₃₄H₃₂NO₁₁P
Molecular Weight:661.602
Hs Code.:

Synonyms:{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Suppliers and Price of {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

There total 13 articles about {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 918299-64-6
(2-hydroxypyridin-4-yl)methylphosphonic acid dimethyl ester

: 918299-71-5
{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Guidance literature:: With bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 3h;
DOI:10.1021/jo0617666

Reference yield:

: 6313-54-8
2-chloroisonicotinic acid,

: 918299-71-5
{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / HCl / 60 h / Heating

2: BH₃-THF / tetrahydrofuran / 1.5 h

3: thionyl chloride

4: 65 percent / bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl triflate / acetonitrile / 3 h

With hydrogenchloride; thionyl chloride; bis(trimethylsilyl)trifluoroacetamide; borane-THF; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; acetonitrile; 4: Michaelis-Arbuzov reaction;
DOI:10.1021/jo0617666

Reference yield:

: 127838-58-8
4-hydroxymethylpyridin-2-ol

: 918299-71-5
{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: 65 percent / bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl triflate / acetonitrile / 3 h

With thionyl chloride; bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; 2: Michaelis-Arbuzov reaction;
DOI:10.1021/jo0617666