cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

Base Information

Chemical Name:cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol
CAS No.:87393-32-6
Molecular Formula:C₃₁H₃₂N₂O₃S
Molecular Weight:512.673
Hs Code.:

Synonyms:cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

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Chemical Property of cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

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Technology Process of cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

There total 9 articles about cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4aS,11cR)-1-Benzyl-4a-ethyl-7-(4-methoxy-benzenesulfonyl)-2-methylsulfanyl-5,6,7,11c-tetrahydro-4aH-pyrido[3,2-c]carbazol-1-ium; iodide

: 87393-32-6
cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 25 ℃; for 1h; Yield given;
DOI:10.1021/ja00262a005

Reference yield:

: 87372-38-1
cis-4a-ethyl-1,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-2H-pyrido<3,2-c>carbazol-2-thione

: 87393-32-6
cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

Guidance literature:: With sodium tetrahydroborate; methyl iodide; Yield given. Multistep reaction; 1.) THF, 50 deg C, 4 h, 2.) MeOH, 25 deg C;
DOI:10.1021/ja00359a047

Reference yield:

: 13722-73-1
4-ethylpent-4-enoic acid

: 87393-32-6
cis-4a-ethyl-2,4a,5,6,7,11c-hexahydro-7-<(p-methoxyphenyl)sulfonyl>-1-benzyl-1H-pyrido<3,2-c>carbazol

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

2: 40 percent / chlorobenzene / 5 h / 140 °C

3: 61 percent / Lawesson reagent / hexamethylphosphoric acid triamide / 18 h / 85 °C

4: 75 percent / p-toluenesulfinyl chloride, i-Pr₂NEt / CH₂Cl₂ / 0.5 h / 0 °C

5: tetrahydrofuran / 7 h / 65 °C

6: NaBH₄ / tetrahydrofuran; methanol / 1 h / 25 °C

With Lawessons reagent; 4-methylbenzenesulfinyl chloride; sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; chlorobenzene;
DOI:10.1021/ja00262a005