(R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Base Information

Chemical Name:(R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile
CAS No.:1307230-03-0
Molecular Formula:C₂₂H₂₁N₃O₃
Molecular Weight:375.427
Hs Code.:

Synonyms:(R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

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Chemical Property of (R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

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Technology Process of (R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

There total 4 articles about (R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.4%

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1307230-79-0
(R)-N,5-dihydroxy-5,6,7,8-tetrahydronaphthalene-1-carboximidamide

: 1307230-03-0
(R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Guidance literature:: 3-cyano-4-isopropoxybenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

(R)-N,5-dihydroxy-5,6,7,8-tetrahydronaphthalene-1-carboximidamide; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 16h;

Reference yield:

: 68449-30-9
5-bromo-1-tetralone

: 1307230-03-0
(R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 5 h / 110 °C / Inert atmosphere

2.1: triethylammonium formate / chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll) / 15 h / 30 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 18 h / 70 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

4.2: 16 h / 20 - 90 °C

With hydroxylamine hydrochloride; triethylammonium formate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll); In 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 138764-20-2
5-oxo-5,6,7,8-tetrahydronaphthalene-1-carbonitrile

: 1307230-03-0
(R)-5-(3-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylammonium formate / chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll) / 15 h / 30 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 18 h / 70 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

3.2: 16 h / 20 - 90 °C

With hydroxylamine hydrochloride; triethylammonium formate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll); In ethanol; N,N-dimethyl-formamide;