N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Base Information

Chemical Name:N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide
CAS No.:1017278-88-4
Molecular Formula:Br*C₄₂H₅₂ClN₄O₇S
Molecular Weight:872.32
Hs Code.:

N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Synonyms:N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Suppliers and Price of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

There total 9 articles about N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1017279-03-6
2-(bromomethyl)-1-methyl-5-(methylsulfonyl)pyrrole

: 1017278-82-8
5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1,2-dihydro-3H-benzo[e]indole

: 1017278-88-4
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 72h; Darkness;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017278-95-3
(E)-4-(dimethylaminomethyl)cinnamic acid hydrochloride

: 1017278-88-4
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; acetonitrile / 5.5 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.75 h / 20 °C

2.2: 12 h / 20 °C

3.1: tetrahydrofuran / 72 h / 20 °C / Darkness

With oxalyl dichloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-66-1
methyl (E)-4-(dimethylaminomethyl)cinnamate

: 1017278-88-4
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol; water / 2 h / Reflux

1.2: 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; acetonitrile / 5.5 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.75 h / 20 °C

3.2: 12 h / 20 °C

4.1: tetrahydrofuran / 72 h / 20 °C / Darkness

With oxalyl dichloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.12.007