Technology Process of 4-aniline
There total 1 articles about 4-aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 2h;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, MeOH, water, 5 deg C, 15 min, 2.) acetone, water, 35 deg C
2: 2.) 1N HCl / 1.) sulfolane, 110 deg C, 16 h; 2.) sulfolane, reflux, 8 h
With
copper(I) oxide; hydrogenchloride; sodium nitrite;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, MeOH, water, 5 deg C, 15 min, 2.) acetone, water, 35 deg C
2: 2.) 1N HCl / 1.) sulfolane, 110 deg C, 16 h; 2.) sulfolane, reflux, 8 h
3: 1.) conc. H2SO4; 2.) HCl / 1.) AcOH, 100 deg C, 1 h; 2.) Et2O
With
copper(I) oxide; hydrogenchloride; sulfuric acid; sodium nitrite;
DOI:10.1248/cpb.30.3580
