N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide

Base Information

Chemical Name:N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide
CAS No.:1334162-91-2
Molecular Formula:C₁₉H₂₉NO₅Si
Molecular Weight:379.528
Hs Code.:

Synonyms:N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide

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Chemical Property of N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide

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Technology Process of N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide

There total 2 articles about N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1334162-90-1
N-(2,3,4-trimethoxyphenyl)but-2-ynamide

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1334162-91-2
N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide

Guidance literature:: N-(2,3,4-trimethoxyphenyl)but-2-ynamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 65h;
DOI:10.1002/cmdc.201100154

Reference yield:

: 50625-48-4
2,3,4-trimethoxyaniline

: 1334162-91-2
N-[(2-(trimethylsilyl)ethoxy)methyl]-N-(2,3,4-trimethoxyphenyl)but-2-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 65 h / 20 °C

With sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/cmdc.201100154