1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

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Chemical Name:1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea
CAS No.:798574-48-8
Molecular Formula:C₃₂H₃₄N₂O₇
Molecular Weight:558.631
Hs Code.:

Synonyms:1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

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Chemical Property of 1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

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Technology Process of 1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

There total 6 articles about 1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 60778-73-6,6192-00-3
β-methoxyacrylic acid chloride

: 3315-16-0
silver cyanate

: 798574-44-4
(2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-ylamine

: 798574-48-8
1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

Guidance literature:: β-methoxyacrylic acid chloride; silver cyanate; In toluene; for 0.5h; Heating;

(2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-ylamine; In toluene; at 0 - 20 ℃; for 1.5h; Further stages.;
DOI:10.1016/j.tet.2004.08.087

Reference yield:

: 76-83-5
trityl chloride

: 798574-48-8
1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / pyridine / 24 h / 20 °C

2.1: 89 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: 79 percent / NaN₃ / dimethylformamide / 24 h / 85 °C

4.1: 98 percent / H₂ / Pd/C / ethyl acetate; ethanol / 4 h / 20 °C / 1551.49 Torr

5.1: toluene / 0.5 h / Heating

5.2: 88 percent / toluene / 1.5 h / 0 - 20 °C

With pyridine; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2004.08.087

Reference yield:

: 258336-20-8
2,5-anhydro-3-deoxy-L-talose ethylene acetal

: 798574-48-8
1-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-3-((E)-3-methoxy-acryloyl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / pyridine / 24 h / 20 °C

2.1: 89 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: 79 percent / NaN₃ / dimethylformamide / 24 h / 85 °C

4.1: 98 percent / H₂ / Pd/C / ethyl acetate; ethanol / 4 h / 20 °C / 1551.49 Torr

5.1: toluene / 0.5 h / Heating

5.2: 88 percent / toluene / 1.5 h / 0 - 20 °C

With pyridine; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2004.08.087