5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

Base Information

Chemical Name:5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid
CAS No.:1467058-68-9
Molecular Formula:C₁₇H₁₃ClN₂O₄
Molecular Weight:344.754
Hs Code.:

Synonyms:5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

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Chemical Property of 5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

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Technology Process of 5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

There total 4 articles about 5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1467061-16-0
2-[4-(6-chloro-3-formyl-1H-indol-5-yl)phenoxy]acetamide

: 1467058-68-9
5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; acetonitrile; tert-butyl alcohol; at 0 - 20 ℃; for 48h;

Reference yield:

: 1878-91-7
(4-bromophenoxy)acetic acid

: 1467058-68-9
5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere; Sealed tube

3: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; acetonitrile; tert-butyl alcohol / 48 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 122531-09-3
5-bromo-6-chloro-1H-indole

: 1467058-68-9
5-[4-(2-amino-2-oxoethoxy)phenyl]-6-chloro-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dimethyl sulfoxide / 1 h / 100 °C

2: N,N-dimethyl(methylene)ammonium chloride / 1,4-dioxane / 0.17 h / 20 °C / Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere; Sealed tube

4: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; acetonitrile; tert-butyl alcohol / 48 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; N,N-dimethyl(methylene)ammonium chloride; potassium acetate; potassium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;