1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

Base Information

Chemical Name:1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester
CAS No.:878479-16-4
Molecular Formula:C₃₂H₃₁N₃O₅
Molecular Weight:537.615
Hs Code.:

Synonyms:1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

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Chemical Property of 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

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Technology Process of 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

There total 15 articles about 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4928-88-5
methyl 1H-1,2,4-triazole-3-carboxylate

: 878479-16-4
1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

Guidance literature:: (3aS,4S,6aR)-2,2-dimethyl-6-[(trityloxy)methyl]-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -78 - 0 ℃; for 1h;

methyl 1H-1,2,4-triazole-3-carboxylate; In tetrahydrofuran; at -78 - 20 ℃; for 24h;

Reference yield:

: 163226-45-7
(3aS,4S,6aR)-2,2-dimethyl-6-[(triphenylmethoxy)methyl]-2H,3aH,4H,6aH-cyclopenta[d][1,3]dioxol-4-ol

: 4928-88-5
methyl 1H-1,2,4-triazole-3-carboxylate

: 878479-16-4
1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jm0509750

Reference yield:

: 934816-38-3
1-[5-(1-(hydroxymethyl)vinyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]prop-2-en-1-ol

: 878479-16-4
1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / second-generation Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

2: 92 percent / 4-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 12 h / 20 °C

3: Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/jm0509750