benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

Base Information

Chemical Name:benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate
CAS No.:870133-57-6
Molecular Formula:C₅₅H₆₈F₃NO₁₁
Molecular Weight:976.14
Hs Code.:

Synonyms:benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

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Chemical Property of benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

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Technology Process of benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

There total 3 articles about benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (2S,4R,5S)-2-(4-Methoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

: 870250-90-1
benzyl 3α,7α-dihydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

: 870133-57-6
benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 80 ℃; for 16h;
DOI:10.1002/ejoc.200500203

Reference yield:

: 130782-08-0
3α,7α-dihydroxy-12α-trifluoroacetoxy-5β-cholan-24-oic acid

: 870133-57-6
benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 1.5 h / 20 °C

2: 67 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 16 h / 80 °C

With dmap; dicyclohexyl-carbodiimide; In toluene;
DOI:10.1002/ejoc.200500203

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 870133-57-6
benzyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 1.5 h / 20 °C

2: 67 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 16 h / 80 °C

With dmap; dicyclohexyl-carbodiimide; In toluene;
DOI:10.1002/ejoc.200500203