(R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

Base Information

Chemical Name:(R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol
CAS No.:1026843-88-8
Molecular Formula:C₃₀H₄₃NO₂Si
Molecular Weight:477.762
Hs Code.:

Synonyms:(R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

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Chemical Property of (R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

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Technology Process of (R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

There total 1 articles about (R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 150131-85-4
(R)-3-<(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl>cyclohexanone

: 1026843-88-8
(R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

Guidance literature:: With sec.-butyllithium; Yield given. Multistep reaction; 1.) cyclohexane, Et₂O, -78 deg C, 30 min, 2.) cyclohexane, Et₂O, THF, a) -78 deg C, 4 h, b) 25 deg C, overnight;

Reference yield:

: 1026843-88-8
(R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

: (R)-1,2,3,6-tetrahydro-4-phenyl-1-<<5-<4-<(tert-butyldimethylsilyl)oxy>phenyl>cyclohexen-1-yl>methyl>pyridine

: 1026801-76-2
(R)-1,2,3,6-tetrahydro-4-phenyl-1-<<3-<4-<(tert-butyldimethylsilyl)oxy>phenyl>cyclohexen-1-yl>methyl>pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 1026843-88-8
(R)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-cyclohexanol

: 163239-24-5
PD 147693

Guidance literature:: Multi-step reaction with 2 steps

1: 2.25 g / CF₃CO₂H / CH₂Cl₂ / 2 h / 25 °C

2: 81 percent / n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With tetrabutyl ammonium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;