(6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester
• CAS No.: 103930-60-5
• Molecular Formula: C₃₂H₃₇N₅O₁₁S₂
• Molecular Weight: 731.805
• Mol file: 103930-60-5.mol

Synonyms:(6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property of (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 4 articles about (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-nitrobenzyl 7β-(2-thienylacetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate (41625-53-0) → (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (103930-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TMSI / CH₂Cl₂

2: NaHCO₃ / dimethylformamide / Ambient temperature

With trimethylsilyl iodide; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00267a045

Reference yield:

1-(2-Diazo-ethyl)-4-nitro-benzene (100206-68-6) → (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (103930-60-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethyl acetate

2: TMSI / CH₂Cl₂

3: NaHCO₃ / dimethylformamide / Ambient temperature

With trimethylsilyl iodide; sodium hydrogencarbonate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja00267a045

Reference yield:

cephalothin (153-61-7) → (6R,7R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (103930-60-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethyl acetate

2: TMSI / CH₂Cl₂

3: NaHCO₃ / dimethylformamide / Ambient temperature

With trimethylsilyl iodide; sodium hydrogencarbonate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja00267a045

upstream raw materials:

N-tert-butoxycarbonyl-L-alanyl-L-alanine

(6R,7R)-3-Iodomethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

p-nitrobenzyl 7β-(2-thienylacetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate

1-(2-Diazo-ethyl)-4-nitro-benzene