2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Base Information

Chemical Name:2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester
CAS No.:74726-84-4
Molecular Formula:C₂₆H₃₄O₆S
Molecular Weight:474.618
Hs Code.:

Synonyms:2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

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Chemical Property of 2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

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Technology Process of 2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

There total 6 articles about 2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 74726-78-6
1-iodo-2-phenylthiomethyl-4,6-dimethoxy-benzene

: 74726-79-7
5-(tetrahydropyran-2-yloxy)pentan-2-ol

: 74726-84-4
2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Guidance literature:: With triethylamine; palladium dichloride; In benzene; at 80 - 100 ℃; for 10h; under 9120 Torr;
DOI:10.1246/cl.1980.369

Reference yield:

: 19491-18-0
methyl 2-bromo-3,5-dimethoxybenzoate

: 74726-84-4
2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / lithium aluminium hydride / diethyl ether / 0 °C

2: 1.) n-BuLi, 2.) iodine / 1.) THF, -78 deg C, 2.) -40 deg C

3: SOCl₂

4: sodium ethoxide

5: 68 percent / NEt₃ / PdCl₂ / benzene / 10 h / 80 - 100 °C / 9120 Torr

With lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; iodine; sodium ethanolate; triethylamine; palladium dichloride; In diethyl ether; benzene;
DOI:10.1246/cl.1980.369

Reference yield:

: 2150-37-0
methyl 3,5-dimethoxybenzoate

: 74726-84-4
2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 1-methyl-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / CCl₄ / 6 h / Heating; Irradiation

2: 52 percent / lithium aluminium hydride / diethyl ether / 0 °C

3: 1.) n-BuLi, 2.) iodine / 1.) THF, -78 deg C, 2.) -40 deg C

4: SOCl₂

5: sodium ethoxide

6: 68 percent / NEt₃ / PdCl₂ / benzene / 10 h / 80 - 100 °C / 9120 Torr

With lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; bromine; iodine; sodium ethanolate; triethylamine; palladium dichloride; In tetrachloromethane; diethyl ether; benzene;
DOI:10.1246/cl.1980.369