2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid

Base Information

Chemical Name:2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid
CAS No.:142385-36-2
Molecular Formula:C₃₁H₄₀N₂O₄
Molecular Weight:504.67
Hs Code.:

Synonyms:2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid

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Chemical Property of 2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid

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Technology Process of 2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid

There total 2 articles about 2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 142385-35-1
2-butyl-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

: 142385-36-2
2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00103a014

Reference yield:

: 67556-07-4
2-oxo-3-ethoxycarbonyl-3Z-pentene

: 142385-36-2
2-butyl-1-<2'-<(1,1'-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,6-dihydro-4,6-dimethyl-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide, 2.) p-toluenesulfonic acid / 1.) DMF, 0 deg C, 15 min, 2.) DMF, a) 80 deg C, 16 h, b) 100 deg C, 1.5 h

2: 72.5 percent / potassium carbonate / dimethylformamide / Ambient temperature

With potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00103a014