1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

Base Information

Chemical Name:1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine
CAS No.:154078-19-0
Molecular Formula:C₂₄H₃₃NO₂
Molecular Weight:367.532
Hs Code.:

Synonyms:1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

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Chemical Property of 1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

Chemical Property:

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Technology Process of 1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

There total 6 articles about 1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 154078-18-9
1-acetyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

: 154078-19-0
1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/hlca.19930760720

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 154078-19-0
1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / Mg / tetrahydrofuran / 3 h / 20 °C

2: 87 percent / TsOH*H₂O / toluene / 2 h / Heating

3: 84 percent / BF₃*Et₂O / 2 h / 85 °C

4: 91 percent / 85percent KOH / dimethylformamide; H₂O / 1 h / Heating

5: 83 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19930760720

Reference yield:

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 154078-19-0
1-ethyl-4-(4-methoxy-3,5-dimethylphenyl)-4-(4-methoxy-3-methylphenyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / Mg / tetrahydrofuran / 3 h / 20 °C

2: 87 percent / TsOH*H₂O / toluene / 2 h / Heating

3: 84 percent / BF₃*Et₂O / 2 h / 85 °C

4: 91 percent / 85percent KOH / dimethylformamide; H₂O / 1 h / Heating

5: 83 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19930760720