(R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

Base Information

Chemical Name:(R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile
CAS No.:1283539-09-2
Molecular Formula:C₁₂H₁₅NO₂
Molecular Weight:205.257
Hs Code.:

Synonyms:(R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

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Technology Process of (R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

There total 4 articles about (R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1283539-04-7
(+/-)-1-cyanomethyl-2-[(4-methylbenzyl)oxy]ethyl acetate

: (S)-1-cyanomethyl-2-[(4-methylbenzyl)oxy]ethyl acetate

: 1283539-09-2
(R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

Guidance literature:: With Novozym 435; at 5 ℃; for 24h; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1016/j.molcatb.2010.02.008

Reference yield:

: 1283539-16-1
4-(4-methylbenzyl)oxy-3-oxobutanenitrile

: 922735-29-3
(S)-4-(4-methylbenzyloxy)-3-hydroxybutanenitrile

: 1283539-09-2
(R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

Guidance literature:: With whole-cell Candida floricola JCM 9439; air; at 30 ℃; for 24h; pH=Ca. 4; optical yield given as %ee; enantioselective reaction; aq. glucose medium; Microbiological reaction;
DOI:10.1016/j.molcatb.2010.02.008

Reference yield:

: 1283539-04-7
(+/-)-1-cyanomethyl-2-[(4-methylbenzyl)oxy]ethyl acetate

: (S)-1-cyanomethyl-2-[(4-methylbenzyl)oxy]ethyl acetate

: (R)-1-cyanomethyl-2-[(4-methylbenzyl)oxy]ethyl acetate

: 1283539-09-2
(R)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile

Guidance literature:: With Novozym 435; at 5 ℃; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1016/j.molcatb.2010.02.008