methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

Base Information

Chemical Name:methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate
CAS No.:681180-44-9
Molecular Formula:C₂₃H₃₄O₄S
Molecular Weight:406.587
Hs Code.:

Synonyms:methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

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Chemical Property of methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

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Technology Process of methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

There total 12 articles about methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl (2E/Z,5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hex-2-enoate

: 681180-44-9
methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h;
DOI:10.1002/ejoc.200300611

Reference yield:

: 332950-58-0
S-tert-butyl (2S)-2-[(1S,5R,7aS)-5-hydroxy-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-3-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]propanethioate

: 681180-44-9
methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

2: 78 percent / Et₃N; DMPA / CH₂Cl₂ / 0 °C

3: 96 percent / mCPBA / CH₂Cl₂ / 2 h / 20 °C

4: 63 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / Heating

5: 80 percent / Amberlist-15H(R) / methanol / 72 h / 20 °C

6: Pb(OAc)4; K₂CO₃ / CH₂Cl₂ / -15 - 20 °C

7: acetonitrile / 3 h / Heating

8: 100 percent / H₂ / Pd on charcoal / ethyl acetate / 4 h

With lead(IV) acetate; lithium aluminium tetrahydride; Amberlist-15H(R); 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1002/ejoc.200300611

Reference yield:

: (S)-3-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-butyraldehyde

: 681180-44-9
methyl (5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 3 h / Heating

2: 100 percent / H₂ / Pd on charcoal / ethyl acetate / 4 h

With hydrogen; palladium on activated charcoal; In ethyl acetate; acetonitrile;
DOI:10.1002/ejoc.200300611