[2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester

Base Information

• Chemical Name: [2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester
• CAS No.: 1027290-33-0
• Molecular Formula: C₁₆H₂₂N₂O₃
• Molecular Weight: 290.362
• Mol file: 1027290-33-0.mol

Synonyms:[2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester

Chemical Property of [2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of [2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester

There total 1 articles about [2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + α-bromo-4-(1-pyrrolidino)acetophenone (216144-18-2) → [2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester (1027290-33-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3.33333h;

DOI:10.1021/ol030065h

Reference yield:

[2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester (1027290-33-0) → (3R,8aS)-3-Methyl-8a-(4-pyrrolidin-1-yl-phenyl)-hexahydro-oxazolo[3,2-a]pyrazin-5-one

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / tetrahydrofuran; H₂O / 18 h / 20 °C

2: lithium hydroxide / tetrahydrofuran; H₂O / 2 h / 20 °C

3: camphorsulfonic acid / toluene / 20 h / Heating

4: hydrogen / wet palladium on carbon / ethanol; ethyl acetate / 2 h / 20 °C

With lithium hydroxide; camphor-10-sulfonic acid; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; toluene;

DOI:10.1021/ol030065h

Reference yield:

[2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethylamino]-acetic acid ethyl ester (1027290-33-0) → (3R,8aS)-3-Phenyl-8a-(4-pyrrolidin-1-yl-phenyl)-hexahydro-oxazolo[3,2-a]pyrazin-5-one

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / tetrahydrofuran; H₂O / 18 h / 20 °C

2: lithium hydroxide / tetrahydrofuran; H₂O / 2 h / 20 °C

3: camphorsulfonic acid / toluene / 20 h / Heating

4: hydrogen / wet palladium on carbon / ethanol; ethyl acetate / 2 h / 20 °C

With lithium hydroxide; camphor-10-sulfonic acid; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; toluene;

DOI:10.1021/ol030065h

upstream raw materials:

glycine ethyl ester hydrochloride

α-bromo-4-(1-pyrrolidino)acetophenone

Downstream raw materials:

{benzyloxycarbonyl-[2-oxo-2-(4-pyrrolidin-1-yl-phenyl)-ethyl]-amino}-acetic acid