tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

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Chemical Name:tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate
CAS No.:1569905-83-4
Molecular Formula:C₂₈H₃₅N₅O₅
Molecular Weight:521.616
Hs Code.:

Synonyms:tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

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Chemical Property of tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

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Technology Process of tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

There total 7 articles about tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1569905-74-3
tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

: 1569905-83-4
tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

Guidance literature:: tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; toluene; at -78 ℃; Inert atmosphere;

With acetic acid; In tetrahydrofuran; toluene; at -78 - 30 ℃; Inert atmosphere;
DOI:10.1055/s-0033-1339892

Reference yield:

: C₂₃H₃₅NO₅

: 1569905-83-4
tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

2.3: -78 - 30 °C / Inert atmosphere

With n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; hexane; toluene;
DOI:10.1055/s-0033-1339892

Reference yield:

: 1569905-46-9
methyl (2E)-3-[2-(3-bromopropyl)-6-methylphenyl]prop-2-enoate

: 1569905-83-4
tert-butyl N-[3-(2-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}-3-methylphenyl)propyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 90 °C / Sealed tube

2.1: hydrogen; palladium 10% on activated carbon / methanol / 8 h

3.1: sodium hydroxide / methanol; water / 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

5.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

6.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 °C / Inert atmosphere

6.3: -78 - 30 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-0033-1339892