1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

Base Information

Chemical Name:1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one
CAS No.:1422434-19-2
Molecular Formula:C₃₄H₃₄Cl₂N₆O₃
Molecular Weight:645.588
Hs Code.:

Synonyms:1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

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Chemical Property of 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

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Technology Process of 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

There total 9 articles about 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₄₂Cl₂N₆O₅

: 1422434-19-2
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1039/c2ob26710a

Reference yield:

: 1422434-48-7
C₃₅H₃₅Cl₂N₅O₆

: 1422434-19-2
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / tetrahydrofuran / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2ob26710a

Reference yield:

: C₃₄H₃₃Cl₂N₅O₆

: 1422434-19-2
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(piperidine-1-carbonyl)phenoxy)-1H-[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c2ob26710a