2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

Base Information

Chemical Name:2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine
CAS No.:606971-30-6
Molecular Formula:C₃₀H₃₀F₆N₆O₂
Molecular Weight:620.598
Hs Code.:

Synonyms:2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

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Chemical Property of 2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

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Technology Process of 2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

There total 8 articles about 2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 606971-80-6
6-[3,5-bis(trifluoromethyl)benzyl]-4-(2-methylphenyl)-2-methylsulfonyl-5,6,7,8,9,10-hexahydropyrimido[4,5-b][1,5]diazocin-5-one

: 13889-98-0
N-acetylpiperidine

: 606971-30-6
2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; Heating;
DOI:10.1016/j.bmc.2005.06.015

Reference yield: 75.0%

: 606971-30-6
2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

Guidance literature:

Reference yield:

: 785046-14-2
4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid (3-amino-propyl)-(3,5-bis-trifluoromethyl-benzyl)-amide

: 606971-30-6
2-(4-acetylpiperazine-1-yl)-6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

Guidance literature:: Multi-step reaction with 4 steps

1: 23.4 g / potassium carbonate / dimethylformamide / 1 h / 80 °C

2: 99 percent / Na₂CO₃ / Pd(PPh₃)4 / toluene; dioxane / Heating

3: 65 percent / m-chloroperbenzoic acid / tetrahydrofuran / 0 - 20 °C

4: 75 percent / ethyldiisopropylamine / dioxane / Heating

With sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2005.06.015