5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

Base Information

Chemical Name:5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one
CAS No.:941594-27-0
Molecular Formula:C₂₈H₃₅N₃O₄SSi
Molecular Weight:537.755
Hs Code.:

Synonyms:5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

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Chemical Property of 5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

Chemical Property:

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Technology Process of 5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

There total 14 articles about 5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 941594-26-9
5-(2-benzyloxy-4-iodomethylphenyl)-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

: 54453-91-7
2-bromo-4-ethylpyridine

: 941594-27-0
5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

Guidance literature:: 5-(2-benzyloxy-4-iodomethylphenyl)-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one; With chloro-trimethyl-silane; ethylene dibromide; zinc; In N,N-dimethyl acetamide; for 0.5h;

2-bromo-4-ethylpyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; In N,N-dimethyl-formamide; at 120 ℃; for 0.833333h; Microwave heating;

Reference yield:

: 1057341-60-2
2-benzyloxy-4-iodophenylamine

: 941594-27-0
5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

2.1: dichloromethane / 0 °C

2.2: 0.5 h / 0 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 19 h

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 3 h / 20 °C

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine / acetonitrile / 18 h / 80 °C

6.2: 0.25 h

7.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

7.2: 1 h

8.1: triethylsilane / iododioxobis(triphenylphosphine)rhenium(V) / benzene / 18 h / 60 °C

9.1: trifluoroacetic acid / methanol / 1 h

10.1: 1H-imidazole; PS-triphenylphosphine; iodine / dichloromethane / 2.5 h / 0 - 45 °C

11.1: chloro-trimethyl-silane; ethylene dibromide; zinc / N,N-dimethyl acetamide / 0.5 h

11.2: 0.83 h / 120 °C / Microwave heating

With 1H-imidazole; triethylsilane; osmium(VIII) oxide; chloro-trimethyl-silane; PS-triphenylphosphine; di-isopropyl azodicarboxylate; iodine; potassium carbonate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethylene dibromide; triethylamine; triphenylphosphine; trifluoroacetic acid; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iododioxobis(triphenylphosphine)rhenium(V); tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; benzene;

Reference yield:

: 1057340-17-6
2-benzyloxy-4-iodo-1-nitrobenzene

: 941594-27-0
5-[2-benzyloxy-4-(4-ethylpyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanyl-ethyl)-1,2,5-thiadiazolidin-3-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: iron; acetic acid / ethanol / 1.5 h / 100 °C / Heating / reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

3.1: dichloromethane / 0 °C

3.2: 0.5 h / 0 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 19 h

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 3 h / 20 °C

7.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine / acetonitrile / 18 h / 80 °C

7.2: 0.25 h

8.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

8.2: 1 h

9.1: triethylsilane / iododioxobis(triphenylphosphine)rhenium(V) / benzene / 18 h / 60 °C

10.1: trifluoroacetic acid / methanol / 1 h

11.1: 1H-imidazole; PS-triphenylphosphine; iodine / dichloromethane / 2.5 h / 0 - 45 °C

12.1: chloro-trimethyl-silane; ethylene dibromide; zinc / N,N-dimethyl acetamide / 0.5 h

12.2: 0.83 h / 120 °C / Microwave heating

With 1H-imidazole; triethylsilane; osmium(VIII) oxide; chloro-trimethyl-silane; PS-triphenylphosphine; di-isopropyl azodicarboxylate; iodine; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethylene dibromide; triethylamine; triphenylphosphine; trifluoroacetic acid; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iododioxobis(triphenylphosphine)rhenium(V); tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; benzene;